japanese

Publications

Original Article

  1. Kaito S, Aoyama K, Oshima M, Tsuchiya A, Miyota M, Yamashita M, Koide S, Nakajima-Takagi Y, Kozuka-Hata H, Oyama M, Yabushita T, Ueno M, Hirao A, Tohyama K, Yamaguchi K,  Furukawa Y, Kosako H, Yoshimi A, Goyama S, Nannya Y, Ogawa S, Agger K, Helin K, Koseki H, Nishiyama A, Nakanishi M, and Iwama A, Inhibition of TOPORS ubiquitin ligase augments the efficacy of DNA hypomethylating agents through DNMT1 stabilization, Nat. Commun., 2024 Aug 28;15(1):7359
  2. Rizq O, Mimura N, Oshima M, Momose S, Takayama N, Itokawa N, Koide S, Shibamiya A, Miyamoto-Nagai Y, Rizk M, Nakajima-Takagi Y, Aoyama K, Wang C, Saraya A, Seimiya M, Watanabe M, Yamasaki S, Shibata T, Yamaguchi K, Furukawa Y, Chiba T, Sakaida E, Nakaseko Chiaki, Tamaru J, Tai Y, Anderson KC, Honda H, and Iwama A. UTX inactivation in germinal center B cells promotes the development of multiple myeloma with extramedullary disease. Leukemia, 2023 Sep;37(9):1895-1907.
  3. Shibamiya A, Miyamoto-NagaiY, KoideS, OshimaM, RizqO, AoyamaK, Y Nakajima-TakagiY, KatoR, KayamoriK, IsshikiY, Oshima-HasegawaN, MutoT, TsukamotoS, TakedaY, Koyama-NasuR, ChibaT, HondaH, YokoteK, IwamaA, SakaidaE, and MimuraN. The pathogenetic significance of exhausted T cells in a mouse model of mature B cell neoplasms. Cancer Immunol Immunother., 2023 Aug;72(8):2635-2648.
  4. Nakajima-Takagi Y, Oshima M, Takano J, Koide S, Itokawa N, Uemura S, Yamashita M, Andoh S, Aoyama K, Isshiki Y, Shinoda D, Saraya A, Arai F, Yamaguchi K, Furukawa Y, Koseki H, Ikawa T, and Iwama A. Polycomb repressive complex 1.1 coordinates homeostatic and emergency myelopoiesis. eLife, 2023 Jun 2;12:e83004
  5. Shiroshita K, Kobayashi H, Watanuki S, Karigane D, Sorimachi Y, Fujita S, Tamaki S, Haraguchi M, Itokawa N, Aoyama K, Koide S, Masamoto Y, Kobayashi K, Nakamura-Ishizu A, Kurokawa M, Iwama A, Okamoto S, Kataoka K, and Takubo K. A culture platform to study quiescent hematopoietic stem cells following genome editing. Cell Rep. Methods, 2022 Dec 5;2(12):100354. 
  6. Uemura S, Yamashita M, Aoyama K, Yokomizo-Nakano T, Oshima M, Nishio M, Masuko M, Takizawa J, Sone H, Yamada Y, Suzuki A, and Iwama A. YAP1/TAZ activity maintains vascular integrity and organismal survival. Biochem. Biophys. Res. Commun., 2022 Jun 19;619:117-123.
  7. Itokawa N, Oshima M, Koide S, Takayama N, Kuribayashi W, Nakajima-Takagi Y, Aoyama K, Yamazaki S, Yamaguchi K, Furukawa Y, Eto K, and Iwama A. Epigenetic traits inscribed in chromatin accessibility in aged hematopoietic stem cells. Nat. Commun., 2022 May 16;13(1):2691.
  8. Shinoda D, Nakajima-Takagi Y, Oshima M, Koide S, Aoyama K, Saraya A, Harada H, Rahmutulla B, Kaneda A, Yamaguchi K, Furukawa Y, Koseki H, Shimoda K, Tanaka T, Sashida G, and Iwama A. Insufficiency of non-canonical PRC1 synergizes with JAK2V617F in the development of myelofibrosis. Leukemia, 2022 Feb;36(2):452-463.
  9. Kusakabe Y, ChibaT, OshimaM, Koide S, RizqO, AoyamaK, AoJ, KanekoT, Kanzaki H, KanayamaK, MaedaT, SaitoT, NakagawaR, KobayashiK, KiyonoS, NakamuraM, OgasawaraS, SuzukiE, NakamotoS, YasuiS, MikataR, MuroyamaR, KandaT, MaruyamaH, KatoJ, MimuraN, MaA, JinJ, ZenY, OtsukaM, KanedaA, IwamaA, and KatoN. EZH1/2 inhibition augments the anti-tumor effects of sorafenib in hepatocellular carcinoma. Sci. Rep., 2021 Nov 1;11(1):21396.
  10. Aoyama K#,* (#co-corresponding author, *co-first author), Shinoda D*, Suzuki E, Nakajima-Takagi Y, Oshima M, Koide S, Rizq O, Si S, Tara S, Sashida G, and Iwama A#. PRC2 insufficiency causes p53-dependent dyserythropoiesis in myelodysplastic syndrome. Leukemia, 2021 Apr; 35(4):1156-1165.
  11. Nitta E, Itokawa N, Yabata S, Koide S, Hou LB, Oshima M, Aoyama K, Saraya A, and Iwama A. Bmi1 counteracts hematopoietic stem cell aging by repressing target genes and enforcing the stem cell gene signature. Biochem. Biophys. Res. Commun., 2020 Jan 15; 521(3):612-619.
  12. Mashimo M*, Bu X*, Aoyama K* (*co-first author), Kato J, Ishiwata-Endo H, Stevens LA, Kasamatsu A, Wolfe LA, Toro C, Adams D, Markello T, Gahl TW, and Moss J. PARP1 inhibition alleviates injury in ARH3-deficient mice and human cells. JCI Insight,2019 Feb 21; 4(4): e124519.
  13. Isshiki Y, Nakajima-Takagi Y, Oshima M, Aoyama K, Rizk M, Kurosawa S, Saraya A, Kondo T, Sakaida E, Nakaseko C, Yokote K, Koseki H, and Iwama A. KDM2B in polycomb repressive complex 1.1 functions as a tumor suppressor in the initiation of T-cell leukemogenesis. Blood Adv., 2019 Sep 10; 3(17):2537-2549.
  14. Kato Y, Hou LB, Miyagi S, Nitta E, Aoyama K, Shinoda D, Yamazaki S, Kuribayashi W, Isshiki Y, Koide S, Si S, Saraya A, Matsuzaki Y, van Lohuizen M, and Iwama A. Bmi1 restricts the adipogenic differentiation of bone marrow stromal cells to maintain the integrity of the hematopoietic stem cell niche. Exp. Hematol., 2019 Aug; 76:24-37.
  15. Nakajo H, Ishibashi K, Aoyama K, Kubota S, Hasegawa H, Yamaguchi N, and Yamaguchi N. Role for tyrosine phosphorylation of SUV39H1 histone methyltransferase in enhanced trimethylation of histone H3K9 via neuregulin-1/ErbB4 nuclear signaling. Biochem. Biophys. Res. Commun., 2019 Apr 16; 511(4):765-771.
  16. Nagao Y, Mimura N, Takeda J, Yoshida K, Shiozawa Y, Oshima M, Aoyama K, Saraya A, Koide S, Rizq O, Hasegawa Y, Shiraishi Y, Chiba K, Tanaka H, Nishijima D, Isshiki Y, Kayamori K, Kawajiri-Manako C, Oshima-Hasegawa N, Tsukamoto S, Mitsukawa S, Takeda Y, Ohwada C, Takeuchi M, Iseki T, Misawa S, Miyano S, Ohara O, Yokote K, Sakaida E, Kuwabara S, Sanada M, Iwama A, Ogawa S, and Nakaseko C. Genetic and transcriptional landscape of plasma cells in POEMS syndrome. Leukemia, 2019 Jul; 33(7):1723-1735.
  17. Aoyama K# (#co-corresponding author), Oshima M, Koide S, Suzuki E, Mochizuki-Kashio M, Kato Y, Tara S, Shinoda D, Hiura N, Nakajima-Takagi Y, Sashida G, and Iwama A#. Ezh1 targets bivalent genes to maintain self-renewing stem cells in Ezh2-insufficient myelodysplastic syndrome. iScience,2018 Nov 30; 9:161-174.
  18. Tara S, Isshiki Y, Nakajima-Takagi Y, Oshima M, Aoyama K, Tanaka T, Shinoda D, Koide S, Saraya A, Miyagi S, Manabe I, Matsui H, Koseki H, Bardwell VJ, and Iwama A. Bcor insufficiency promotes initiation and progression of myelodysplastic syndrome. Blood, 2018 Dec 6; 132(23):2470-2483.
  19. Hirata K, Takakura Y, Shibazaki M, Morii M, Honda T, Oshima M, Aoyama K, Iwama A, Nakayama Y, Takano H, Yamaguchi N, and Yamaguchi N. Forkhead box protein A1 confers resistance to transforming growth factor-β-induced apoptosis in breast cancer cells through inhibition of Smad3 nuclear translocation. J. Cell. Biochem., 2019 Feb; 120(2):2259-2270.
  20. Yuki R, Tatewaki T, Yamaguchi N, Aoyama K, Honda T, Kubota S, Morii M, Manabe I, Kuga T, Tomonaga T, and Yamaguchi N. Desuppression of TGF-β signaling via nuclear c-Abl-mediated phosphorylation of TIF1γ/TRIM33 at Tyr-524, -610, and -1048. Oncogene,2019 Jan; 38(5):637-655.
  21. Wang C, Oshima M, Sato D, Matsui H, Kubota S, Aoyama K, Nakajima-Takagi Y, Koide S, Matsubayashi J, Mochizuki-Kashio M, Nakano-Yokomizo T, Bai J, Nagao T, Kanai A, Iwama A, and Sashida G. Ezh2 loss propagates hypermethylation at T cell differentiation-regulating genes to promote leukemic transformation. J. Clin. Invest., 2018 Aug 31; 128(9):3872-3886.
  22. Fujita S, Honma D, Adachi N, Araki K, Takamatsu E, Katsumoto T, Yamagata K, Akashi K, Aoyama K, Iwama A, and Kitabayashi I. 2018. Dual inhibition of EZH1/2 breaks the quiescence of leukemia stem cells in acute myeloid leukemia. Leukemia, 2018 Apr; 32(4):855-864.
  23. Ueda K, Ikeda K, Ikezoe T, Harada-Shirado K, Ogawa K, Hashimoto Y, Sano T, Ohkawara H, Kimura S, Shichishima-Nakamura A, Nakamura Y, Shikama Y, Mori T, Mason PJ, Bessler M, Morishita S, Komatsu N, Shide K, Shimoda K, Koide S, Aoyama K, Oshima M, Iwama A, and Takeishi Y. Hmga2 collaborates with JAK2V617F in the development of myeloproliferative neoplasms. Blood Adv., 2017 Jun 14; 1(15):1001-1015.
  24. Tanaka T*, Nakajima-Takagi Y*, Aoyama K* (*co-first author), Tara S, Oshima M, Saraya A, Koide S, Si S, Manabe I, Sanada M, Nakayama M, Masuko M, Sone H, Koseki H, and Iwama A. Internal deletion of BCOR reveals a tumor suppressor function for BCOR in T lymphocyte malignancies. J. Exp. Med., 2017 Oct 2; 214(10):2901-2913.
  25. Kuki K, Yamaguchi N, Iwasawa S, Takakura Y, Aoyama K, Yuki R, Nakayama Y, Kuga T, Hashimoto Y, Tomonaga T, and Yamaguchi N. Enhancement of TGF-β-induced Smad3 activity by c-Abl-mediated tyrosine phosphorylation of its coactivator SKI-interacting protein (SKIP). Biochem. Biophys. Res. Commun.,2017 Aug 26; 490(3):1045-1051.
  26. Rizq O, Mimura N, Oshima M, Saraya A, Koide S, Kato Y, Aoyama K, Nakajima-Takagi Y, Wang C, Chiba T, Ma A, Jin J, Iseki T, Nakaseko C, and Iwama A. Dual Inhibition of EZH2 and EZH1 Sensitizes PRC2-dependent Tumors to Proteasome Inhibition. Clin. Cancer Res.,2017 Aug 15; 23(16):4817-4830.
  27. Yokoyama M, Chiba T, Zen Y, Oshima M, Kusakabe Y, Noguchi Y, Yuki K, Koide S, Tara S, Saraya A, Aoyama K, Mimura N, Miyagi S, Inoue M, Wakamatsu T, Saito T, Ogasawara S, Suzuki E, Ooka Y, Tawada A, Otsuka M, Miyazaki M, Yokosuka O, and Iwama A. Histone lysine methyltransferase G9a is a novel epigenetic target for the treatment of hepatocellular carcinoma. Oncotarget,2017 Mar 28; 8(13):21315-21326.
  28. Honda T, Soeda S, Tsuda K, Yamaguchi C, Aoyama K, Morinaga T, Yuki R, Nakayama Y, Yamaguchi N, and Yamaguchi N. Protective role for lipid modifications of Src-family kinases against chromosome missegregation. Sci. Rep.,2016 Dec 12; 6:38751.
  29. Shimizu R, Muto T, Aoyama K, Choi K, Takeuchi M, Koide S, Hasegawa N, Isshiki Y, Togasaki E, Kawajiri-Manako C, Nagao Y, Tsukamoto S, Sakai S, Takeda Y, Mimura N, Ohwada C, Sakaida E, Iseki T, Starczynowski DT, Iwama A, Yokote K, and Nakaseko C. Possible role of intragenic DNA hypermethylation in gene silencing of the tumor suppressor gene NR4A3 in acute myeloid leukemia. Leukemia Res.,2016 Nov; 50:85-94.
  30. Sashida G, Wang C, Tomioka T, Oshima M, Aoyama K, Kanai A, Mochizuki-Kashio M, Harada H, Shimoda K, and Iwama A. The loss of Ezh2 drives the pathogenesis of myelofibrosis and sensitizes tumor-initiating cells to bromodomain inhibition. J. Exp. Med.,2016 Jul 25; 213(8):1459-1477.
  31. Koide S, Oshima M, Takubo K, Yamazaki S, Nitta E, Saraya A, Aoyama K, Kato Y, Miyagi S, Nakajima-Takagi Y, Chiba T, Matsui H, Arai F, Suzuki Y, Kimura H, Nakauchi H, Suda T, Shinkai Y, and Iwama A. Setdb1 maintains hematopoietic stem and progenitor cells by restricting the ectopic activation of nonhematopoietic genes. Blood,2016 Aug 4; 128(5):638-649. 
  32. Si S, Nakajima-Takagi Y, Aoyama K, Oshima M, Saraya A, Sugishita H, Nakayama M, Ishikura T, Koseki H, and Iwama A. Loss of Pcgf5 affects global H2A monoubiquitination but not the function of hematopoietic stem and progenitor cells. PLoS One,2016 May 2; 11(5):e0154561.
  33. Kameda T, Shide K, Yamaji T, Kamiunten A, Sekine M, Hidaka T, Kubuki Y, Sashida G, Aoyama K, Yoshimitsu M, Abe H, Miike T, Iwakiri H, Tahara Y, Yamamoto S, Hasuike S, Nagata K, Iwama A, Kitanaka A, and Shimoda K. Gene expression profiling of loss of TET2 and/or JAK2V617F mutant hematopoietic stem cells from mouse models of myeloproliferative neoplasms. Genom. Data, 2015 Apr 9; 4:102-108.
  34. Mochizuki-Kashio M, Aoyama K, Sashida G, Oshima M, Tomioka T, Muto T, Wang C, and Iwama A. Ezh2 loss in hematopoietic stem cells predisposes mice to develop heterogeneous malignancies in an Ezh1-dependent manner. Blood, 2015 Sep 3; 126(10):1172-1183.
  35. Yamaguchi N, Yuki R, Kubota S, Aoyama K, Kuga T, Hashimoto Y, Tomonaga T, and Yamaguchi N. c-Abl-mediated tyrosine phosphorylation of JunB is required for Adriamycin-induced expression of p21. Biochem. J., 2015 Oct 1; 471(1):67-77.
  36. Kubota S, Morii M, Yuki R, Yamaguchi N, Yamaguchi H, Aoyama K, Kuga T, Tomonaga T, and Yamaguchi N. Role for tyrosine phosphorylation of A-kinase anchoring protein 8 (AKAP8) in its dissociation from chromatin and the nuclear matrix. J. Biol. Chem.,2015 Apr 24; 290(17):10891-10904.
  37. Aoyama K* (*co-first author), Yamaguchi N*, Yuki R*, Morii M, Kubota S, Hirata K, Abe K, Honda T, Kuga T, Hashimoto Y, Tomonaga T, Yamaguchi N. c-Abl induces stabilization of histone deacetylase 1 (HDAC1) in a kinase activity-dependent manner. Cell. Biol. Int., 2015 Apr; 39(4):446-456.
  38. Yuki R, Aoyama K, Kubota S, Yamaguchi N, Kubota S, Hasegawa H, Morii M, Huang X, Liu K, Williams R, Fukuda MN, and Yamaguchi N. Overexpression of zinc-finger protein 777 (ZNF777) inhibits proliferation at low cell density through down-regulation of FAM129A. J. Cell. Biochem., 2015 Jun; 116(6):954-968.
  39. Kameda T, Shide K, Yamaji T, Kamiunten A, Sekine M, Taniguchi Y, Hidaka T, Kubuki Y, Shimoda H, Marutsuka K, Sashida G, Aoyama K, Yoshimitsu M, Harada T, Abe H, Miike T, Iwakiri H, Tahara Y, Sueta M, Yamamoto S, Hasuike S, Nagata K, Iwama A, Kitanaka A, and Shimoda K. Loss of TET2 has dual roles in murine myeloproliferative neoplasms: disease sustainer and disease accelerator. Blood, 2015 Jan 8; 125(2):304-315.
  40. Kubota S, Fukumoto Y, Ishibashi K, Soeda S, Kubota S, Yuki R, Nakayama Y, Aoyama K, Yamaguchi N, and Yamaguchi N. Activation of the prereplication complex is blocked by mimosine through reactive oxygen species-activated ataxia telangiectasia mutated (ATM) protein without DNA damage. J. Biol. Chem.,2014 Feb 28; 289(9):5730-5746.
  41. Aoyama K, Yuki R, Horiike Y, Kubota S, Yamaguchi N, Morii M, Ishibashi K, Nakayama Y, Kuga T, Hashimoto Y, Tomonaga T, and Yamaguchi N. Formation of long and winding nuclear F-actin bundles by nuclear c-Abl tyrosine kinase. Exp. Cell Res.,2013 Dec 10; 319(20):3251-3268.
  42. Kubota S, Fukumoto Y, Aoyama K, Ishibashi K, Yuki R, Morinaga T, Honda T, Yamaguchi N, Kuga T, Tomonaga T, and Yamaguchi N. Phosphorylation of KRAB-associated protein 1 (KAP1) at Tyr-449, Tyr-458, and Tyr-517 by nuclear tyrosine kinases inhibits the association of KAP1 and heterochromatin protein 1α (HP1α) with heterochromatin. J. Biol. Chem.,2013 Jun 14; 288(24):17871-17883.
  43. Ishibashi K, Fukumoto Y, Hasegawa H, Abe K, Kubota S, Aoyama K, Kubota S, Nakayama Y, and Yamaguchi N. Nuclear ErbB4 signaling through H3K9me3 is antagonized by EGFR-activated c-Src. J. Cell Sci., 2013 Jan 15; 126(Pt 2):625-637.
  44. Aoyama K, Fukumoto Y, Ishibashi K, Kubota S, Morinaga T, Horiike Y, Yuki R, Takahashi A, Nakayama Y, and Yamaguchi N. Nuclear c-Abl-mediated tyrosine phosphorylation induces chromatin structural changes through histone modifications that include H4K16 hypoacetylation. Exp. Cell Res., 2011 Dec 10; 317(20):2874-2903.
  45. Fukumoto Y, Obata Y, Ishibashi K, Tamura N, Kikuchi I, Aoyama K, Hattori Y, Tsuda K, Nakayama Y, and Yamaguchi N. Cost-effective gene transfection by DNA compaction at pH 4.0 using acidified, long shelf-life polyethylenimine. Cytotechnology, 2010 Jan; 62(1):73-82.

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慶應義塾大学 薬学部 衛生化学講座

青山グループ

〒105-8512 東京都港区芝公園1-5-30

Aoyama Group

Division of Hygienic Chemistry
Faculty of Pharmacy, Keio University

1-5-30 Shibakoen, Minato-ku, Tokyo 105-8512

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